Anemia (uh-NEE-mee-uh): any condition in which the number of red blood cells, the amount of hemoglobin, and the volume of packed red blood cells in the blood are lower than normal levels

Chronic Kidney Disease [CKD]: a disease in which kidney function is slowly reduced

Dialysis (dy-AL-ih-sis): kidney replacement therapy in which blood is filtered through a membrane to remove waste products and excess fluid

ESA: erythropoiesis stimulating agent

Erythropoiesis stimulating agent [ESA] (eh-RITH-roh-poy-EE-sis): drug which acts like erythropoietin to stimulate formation of red blood cells

Erythropoietin [EPO] (eh-rith-roh-POY-eh-tin): a protein produced by the kidney that increases the formation of red blood cells

FDA: Food and Drug Administration

Ferritin (FER-uh-tin): an iron-protein complex found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver. It regulates iron storage and transport

Hematocrit [Hct] (heh-MAH-toe-krit): percentage of the volume of a blood sample occupied by cells

Hemodialysis (hee-moh-dy-AL-ih-sis): see dialysis

Hemoglobin [Hb] (hee-moh-GLOH-bin): the oxygen-carrying compound in red blood cells

Iron deficiency: depletion of iron stores to the degree that red blood cell production is impaired

Iron deficiency anemia: anemia accompanied by indicators of low iron status

RBC: red blood cell

TSAT: transferrin saturation (see Transferrin saturation)

Transferrin (trans-FER-in): iron-transporting protein that circulates in the blood

Transferrin saturation [TSAT] (trans-FER-in satch-uh-RAY-shun): the amount of protein-bound iron in circulation

Transfusion (tranz-FYOO-zhun): transfer of blood or blood components from one individual to another
American Regent. Enriching the lives of anemia patients. ™

Important Safety Information

Serious allergic type reactions, including anaphylactic-type reactions, some of which have been life-threatening and resulted in death, have been reported in patients receiving Venofer® (iron sucrose injection, USP). Patients may experience shock, clinically significant hypotension (low blood pressure), loss of consciousness, and/or collapse. If allergic type reactions occur during use, use of Venofer® should stop immediately. Patients should be observed for signs and symptoms of allergic type reactions during and after use of Venofer® for at least 30 minutes and until clinical symptoms are normal. Venofer® should only be given when people, equipment and drugs are immediately available for the treatment of serious allergic type reactions.

Significant hypotension (low blood pressure) has been reported in patients who receive Venofer®. Hypotension (low blood pressure) following administration of Venofer® may be related to how fast and how much of the drug is given.

Venofer® should not be taken if you have symptoms of too much iron in your blood (including low blood pressure, taste disturbance, joint aches, and nausea/vomiting), or if you have a known allergy to Venofer®.

In studies, the most common side effects of Venofer® included a temporary drop in blood pressure, infections, taste disturbance, muscle cramps, swelling of the arms and legs, nausea, headache, and diarrhea. These are not all the possible side effects of Venofer®. For more information ask your healthcare professional or contact American Regent at 1-800-645-1706.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information.